Extremely high priority
06ImportantEvidence: mixed
D3 + K2 supplementation
Priority Matrix
The numbers.
Four dimensions, scored 1–6, where six is always the good end: cheapest, quickest, easiest, highest impact. Priority is Impact squared, divided by what it costs you in energy, money and time.
Cost$15/mo
Time10 sec
EnergyEffortless
ImpactHigh
How sure we are
MixedReal studies disagree, or the effects are small and noisy.
Kept separate from the priority score on purpose: confidence in the evidence never raises how worth-it something is.
What we read
- Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
New England Journal of Medicine · 2019
In 25,871 US adults, 2,000 IU of vitamin D3 daily for 5.3 years did not reduce invasive cancer or major cardiovascular events versus placebo.
- Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis
The Lancet Diabetes & Endocrinology · 2018
Pooling 81 trials, vitamin D supplementation did not reduce fractures or falls, or improve bone mineral density, in community-dwelling adults — most of whom were not deficient.
Research from Brigham and Women's Hospital · University of Auckland. We cite their published work. They have no involvement with Anew.
Where this falls down
Not for everyone. People already sufficient on a 25-OH D test gain little from more pills; megadoses have been harmful in trials.
Still unknown. K2 is bundled here as a theoretical cofactor for calcium handling — that pairing has not been tested at outcome scale the way D3 has, and D3 itself failed its two biggest prevention trials in replete adults.
Topics
Where it fits.
Related products
The gear.
Products that share a topic with this intervention. Same matrix scoring, same restraint.
- Important
Best ValueNutritionThe dessert with a cocoa-flavanol dossier.
Cost$4–8TimeNoneEnergyEffortlessImpactModerate
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